Dimension Inx Announces Issuance of “Tissue Papers” Patent covering a New Family of Biomaterials for Regenerative Medicine Applications

CHICAGO, Illinois, USA – June 29, 2021 – Dimension Inx, a regenerative biomaterials company, announces the issuance of a U.S. patent covering highly porous, mechanically robust advanced bioscaffolds called “Tissue Papers” for tissue and organ repair and regeneration.

Tissue Papers contain bioactive decellularized extracellular matrix (dECM) particles known for their inherent ability to induce new tissue formation. dECM is frequently dissolved or digested and used to create gels or coatings; such materials typically have limited structural integrity, which restrict their practical use.

In contrast, Tissue Papers are mechanically robust enough to be cut, rolled, folded, or sutured, as needed, without breaking, crumpling, or tearing. They act like thin paper-like sponges – initially dry but highly absorbent, presenting an important characteristic for surgical use where the ability to soak up blood and related nutrients is essential.

Novel dECM-based bioscaffolds like Tissue Papers can be applied to repair or regenerate damaged, missing, or dysfunctional tissues and organs, and can play a role in tissue modeling and tissue survival. Dimension Inx Tissue Papers have been used in research to promote the survival and function of human ovarian tissue in the lab; this could present broader applications for drug discovery and development as well as fertility preservation.

“We can imagine a Tissue Paper patch for tissue-specific grafting to repair damaged organs or a bioactive bandaid for wound healing,” said Caralynn Nowinski Collens, M.D., Chief Executive Officer. “These are some of the groundbreaking products we seek to develop in partnership with leading therapeutics and medical device companies.”

U.S. Patent No. 11,045,581, “Surgically-Friendly Tissue Papers from Organ-Specific Decellularized Extracellular Matrices”, describes the composition of these novel bioscaffolds. Each has a unique micro- and nanostructure that is similar to the distinct nature of native tissues and organs. For example, muscle and skin-derived Tissue Papers are relatively stiff with flat microstructures, whereas kidney- and uterus-derived Tissue Papers are relatively soft with highly porous, rough microstructures.

Dimension Inx has exclusive worldwide rights to commercialize this invention as part of a broad intellectual property portfolio licensed from Northwestern University. Inventors and company co-founders, Ramille Shah, Ph.D., and Adam Jakus, Ph.D., developed this portfolio from nearly a decade of research at Northwestern’s Tissue Engineering and Additive Manufacturing Lab.

+ About Dimension Inx

Dimension Inx is the architect of regenerative microenvironments. Our materials give the body a blueprint to heal itself.

We take a materials-centric approach to solving patient needs. Our bioactive materials and structures emulate the body’s microenvironment to elicit a regenerative response. Our patented biomaterials platform and additive manufacturing process are highly adaptable to enable design for biofunctionality and manufacturability. We work with leading product and R&D organizations to co-create a wide variety of clinical applications and accelerate the development of new regenerative solutions.

Dimension Inx is proudly based in Chicago, Illinois.  To learn more about our team and our technology, please visit www.dimensioninx.com.